Integration of medical research and production to promote the transformation of clinical results

On July 17, the National Health Commission issued the ''Guiding Opinions on Promoting Clinical Junior College Capacity Building, ''which once again emphasized focusing on major diseases and key technologies, guided by solving clinical practical problems, and strengthening clinical diagnosis and treatment technology innovation, applied research and results transformation. To comprehensively promote health and health science and technology innovation, and significantly enhance the ability of science and technology to lead and support the construction of a healthy China, it is necessary to accelerate the formation of a health and health science and technology innovation system that meets demand and is coordinated and efficient.

In recent years, China has vigorously promoted the collaborative innovation of "medical research enterprises", strengthened the cooperation of medical institutions, scientific research institutes, colleges and universities, food and drug inspection and testing institutions and enterprises, and built the system mechanism and mode of collaborative innovation. As the country puts forward the "medical research enterprise" collaborative scientific and technological innovation model, the status of medical and health institutions as the main body of innovation has become increasingly prominent, especially research-oriented medical and health institutions have three major functions of medical treatment, scientific research and teaching, and are the main gathering place of innovative achievements. At present, the scientific research paradigm of medical and health institutions has developed to the stage of integration innovation and innovation hub, but the transformation efficiency of scientific and technological achievements is not high, and the vitality of medical, research and industrial innovation subjects has not yet been released, so it is urgent to improve the transformation efficiency through the integration mode.

The key elements of medical research and production integration include the management of intellectual property rights of the main body, the mechanism of interest association and distribution between the main body, the integration channel and service system, and the institutional mechanism of the transformation of the results of medical and health institutions. At present, the exploration in some places has achieved results. For example, Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine Yinhai Eye Hospital to build a "trinity" model of medical research and production, so that "teaching-scientific research-results maturation and transformation-clinical" fast lane smooth, 2019 was included in the State Council's sixth major inspection found a typical experience and practice.

The medical research and production model of Shanghai Tenth People's Hospital plays the role of a technical service integration channel, strengthens the cooperation between hospitals, schools, and enterprises, allows basic research and experimental research to truly transform and move towards the clinic, and strengthens cooperation with various innovation entities in the industrial chain and innovation chain. Close cooperation, and gradually realize the transformation of results into an innovation ecology.

West China Hospital of Sichuan University has stepped up the reform of the system and mechanism. Through the establishment of a standardized management system for the transfer and transformation of achievements, the empowerment of achievements, the improvement of the assessment baton, and the expansion of the autonomy of scientific research personnel, the West China Hospital of Sichuan University has effectively broken through the blocking points of the chain of achievements transformation and stimulated the momentum of achievements transformation.

To promote the construction of a collaborative and efficient health science and technology innovation system, and to analyze and explore the path, experience and problems of pioneers, there are three important implications.

The first is to clarify the positioning of the parties and clarify the relationship of interests.

Establish a working mechanism for the promotion of medical research and industry coordination, clarify the responsibilities of medical and health institutions, scientific research institutes, and enterprises in the mechanism, clarify the tripartite interest relationship and benefit distribution, improve the work process and coordination mechanism of the three, and clarify the knowledge Property cooperation mechanism.

We should straighten out the benefit distribution relationship among clinical, scientific research, transfer and transformation of scientific and technological achievements, support medical and health institutions to strengthen the construction of internal achievement transformation departments, institutions and teams, strengthen the cooperation of scientific research management, talent allocation, asset supervision and fund guarantee, and jointly promote the transformation of achievements. At the same time, promote medical and health institutions and scientific research institutes to accelerate the establishment and improvement of the internal control system for the transformation of scientific and technological achievements in accordance with relevant regulations and policies.

To clarify the interest distribution relationship between the subjects of medical research and research, strengthen the convergence and coordination of the subjects, and break the bottleneck of integration and transformation. Further clarify the responsibilities of the main body of innovation, encourage the leadership of the grassroots units to dare to take responsibility, and clarify specific and operational cooperation rules to eliminate the blind spots and ambiguities that still exist in the transformation of results.

The second is to open up the integration channel and improve the service system.

It provides a docking channel for the three parties of medical research and production, bringing together innovative partners such as local governments, medical and health institutions, universities, scientific research institutes, and enterprises to jointly carry out research and development and achievement transformation for the actual innovation needs of clinical diagnosis and treatment and the industry, so that enterprises can intervene in the transformation of medical research and production achievements as soon as possible and improve the efficiency of transformation and integration. Among them, it is necessary to build a medical research industry integration innovation platform, strengthen common technology research, carry out R & D and transformation services for industrialization, further form a "R & D incubation investment" integration innovation platform, and accelerate the industrialization of results.

Support the development of research outsourcing service institutions, encourage platforms to carry out pre-clinical effectiveness evaluation services aimed at improving the success rate of drug research and development and reducing costs on the basis of most domestic platforms focusing on pre-clinical safety evaluation; encourage medical and health institutions, scientific research institutes and professional service institutions for the transfer and transformation of scientific and technological achievements to cooperate to improve the ability of technology transfer and achievement transformation, establish and improve service systems such as results release, supply and demand docking, and transformation guidelines.

Vigorously cultivate and gather international, high-level professional compound transfer and transformation service talents, and support medical and health institutions and scientific research institutes to clarify the incentive standards for management and service personnel who contribute to the transformation of scientific and technological achievements in the rules and regulations for the transformation of scientific and technological achievements And incentive methods.

The third is to improve the system reform and strengthen the mechanism construction.

We will accelerate the establishment of a full-cycle management system for the transformation of scientific and technological achievements, ensure the coordination of the whole chain system for the transformation of achievements among the three parties, and promote the early intervention of enterprises, social capital and other market entities in the transformation of scientific and technological achievements in the fields of medical and health and life health, so as to improve the efficiency of the transformation of achievements.

Improve the achievement transformation mechanism of medical and health institutions, improve the relevant policies and implementation rules for the transformation of scientific and technological achievements of medical and health institutions, make the path of medical and health institutions to buy shares smooth, and make it clear that scientific researchers in medical and health institutions can enjoy the same preferential tax policies as those in universities and scientific research institutes.

Strengthen the protection of intellectual property rights, according to the characteristics of the transformation of medical research, industry integration and synthesis of fruits, outside the scope of traditional intellectual property rights, strengthen the protection and development of new drugs, hospital preparations, biological products, medical devices, diagnostic reagents, diagnosis and treatment programs and other achievements related to the medical industry, explore the whole process protection and development mechanism of intellectual property rights, and practice the new mode of intellectual property protection.